The project is based on two pillars:
1 The techniques of three-dimensional (3D) printing of biomaterials for the construction of a 3D printed mold of high morphological analysis, which will provide mechanical support, channels for nutrient medium flow and elements for normal stresses transfer to the evolving tissue.
printer took a galley.
2 The low-resolution 3D bioprinting inside the mold, creating the complex implant. Through this procedure, biomaterial with cells will be deposited. The combination of the two methods of additive manufacturing utilizes the advantage of the mechanical properties of the first technique, which does not support cell survival though, and the features of the tissue engineering of the second technique. In parallel, a perfusion/compression bioreactor system will be developed for the biological and mechanical maturation of the CI and the assessment of its biological response.